Cardinals RB James Conner (knee) being placed on injured reserve

The Arizona Cardinals will have to play for a while without the main force of their backfield.

Running back James Conner is being placed on injured reserve due to a knee injury suffered in Sunday’s loss to the Cincinnati Bengals, NFL Network Insiders Ian Rapoport and Tom Pelissero reported Tuesday, per sources informed of the situation. The team has since announced the news on Conner, who will miss a minimum of four games.

In the second quarter of the Week 5 loss, Conner hurt his knee during a 35-yard run and did not come back.

Conner leads the Cards with 364 rushing yards on 68 carries and two touchdowns in five games this season. No other running back from Arizona has managed to rush even 50 yards.

Losing its lead back is a blow to a 1-4 Arizona team that has been plucky to start the season. The Cardinals claimed Tony Jones Jr. off waivers this week from the New Orleans Saints to help fill the void while Conner is out.